Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

Open Access
Authors
  • G.T. Höfler
  • A. But
  • S.H.H. Younes
  • R. Wever
  • C.E. Paul
  • I.W.C.E. Arends
  • F. Hollmann
Publication date 24-02-2020
Journal ACS Sustainable Chemistry & Engineering
Volume | Issue number 8 | 7
Pages (from-to) 2602-2607
Number of pages 6
Organisations
  • Faculty of Science (FNWI) - Van 't Hoff Institute for Molecular Sciences (HIMS)
Abstract The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.
Document type Article
Note With supplementary file
Language English
Published at
Downloads
acssuschemeng.9b07494 (Final published version)
Supplementary materials
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