Later childhood effects of perinatal exposure to background levels of dioxins in the Netherlands

Thesis

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Titlepage

Table of Contents

LIST OF ABBREVIATIONS

INTRODUCTION

1 OPEN CHEMICAL COMBUSTIONS RESULTING IN A LOCAL INCREASED INCIDENCE OF OROFACIAL CLEFTS

2 DECREASED LUNG FUNCTION ASSOCIATED WITH PERINATAL EXPOSURE TO DUTCH BACKGROUND LEVELS OF DIOXINS

3 PERSISTENT HAEMATOLOGICAL AND IMMUNOLOGICAL DISTURBANCES IN DUTCH EIGHT YEAR OLD CHILDREN ASSOCIATED WITH PERINATAL DIOXIN EXPOSURE

4.1 PERINATAL DIOXIN EXPOSURE AND CYTOCHROME P-450 ACTIVITY, THYROID AND LIVER FUNCTIONS AT FOLLOWUP AFTER 7 – 12 YEARS

4.2 VALIDATION OF A HIGHPERFORMANCE LIQUID CHROMATOGRAPHY ASSAY FOR QUANTIFICATION OF CAFFEINE AND PARAXANTHINE IN HUMAN SERUM IN THE CONTEXT OF CYP1A2 PHENOTYPING

5 NEURODEVELOPMENTAL INFLUENCES OF PERINATAL DIOXIN EXPOSURE AS ASSESSED WITH MAGNETOENCEPHALOGRAPHY, ELECTROENCEPHALOGRAPHY, PSYCHOLOGICAL AND NEUROMOTOR TESTS

6 DOES PERINATAL EXPOSURE TO BACKGROUND LEVELS OF DIOXINS HAVE A LASTING EFFECT ON THE HUMAN DENTITION?

SUMMARY

SAMENVATTING

APPENDIX 1:

APPENDIX 2:

A WORD OF THANKS

Publications

Curriculum Vitae

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