Polycomb group genes in brain development and cancer : Ink4a/Arf and beyond

Authors	S.W.M. Bruggeman
Supervisors	M.M.S. Lohuizen
Award date	07-02-2008
ISBN	9075575130=9789075575132
Number of pages	158
Publisher	Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	thesis.pdf Titlepage Table of contents Chapter 1: General introduction: Glued to the brain. A brief description of development and disease of the mammalian brain Chapter 2: Stem cells and cancer: the Polycomb connection Chapter 3: controlling stem cell proliferation: CKIs at work Chapter 4: Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1 deficient mice Chapter 5: Ring1b is required for brain development and neural stem cell proliferation Chapter 6: Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma Chapter 7: Bmi1 deficient neural stem cells have increased Integrin-dependent adhesion to self-secreted matrix Chapter 8: General discussion Summary Nederlandse samenvatting List of publications Curriculum vitae Acknowledgements
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