The function of Tiam1 in tumor cell biology

Authors	T.P. Rygiel
Supervisors	A.J.M. Berns
Cosupervisors	J.G. Collard
Award date	08-05-2009
ISBN	9789085595137
Number of pages	160
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Title pages List of contents Chapter 1: Rho GTPases : physiological role and contribution in tumorigenicity Chapter 2: The Rac activator Tiam1 is a Wnt-target gene implicated in colorectal tumorigenesis Chapter 3: Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice Chapter 4: The Rac activator Tiam1 and Ras-induced oncogenesis Chapter 5: The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation Chapter 6: The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex Summary and conclusions Samenvatting Streszczenie List of publications Curriculum vitae Acknowledgments
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