The bone marrow niche in the pathogenesis of multiple myeloma: A role for Wnt signaling and adrenomedullin

Authors	K.A. Kocemba
Supervisors	S.T. Pals
Cosupervisors	M. Spaargaren
Award date	06-03-2014
ISBN	9788363861162
Number of pages	223
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Title pages Contents Chapter 1: General introduction Chapter 2: Wnt signaling reaching gale force during multiple myeloma progression Chapter 3: Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma Chapter 4: Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease Chapter 5: N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation Chapter 6: The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis Chapter 7: Summary and discussion Nederlandse samenvatting Acknowledgments Curriculum vitae
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