Chemokine receptors in HIV-1 infection and AIDS pathogenesis

Thesis

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Stellingen behorende bij het proefschrift

Titlepage

Contents

Chapter 1 General Introduction

Part 1: Polymorphisms in Chemokines and Chemokine Receptors

Chapter 2 Role of CCR2 genotype in the clinical course of syncytium-inducing (SI) or non-SI human immuno-deficiency virus type 1 infection and in the time to conversion to SI virus variants

Chapter 3 The role of a stromal cell-derived factor-1 chemokine gene variant in the clinical course of HIV-1 infection

Chapter 4 CC-chemokine receptor variants, SDF-1 polymorphism, and disease progression in 720 HIV-infected patients

Chapter 5 Reduced prevalence of the CCR5 ∆32 heterozygous genotype in human immunodeficiency virus-infected individuals with AIDS dementia complex

Chapter 6 Host genetic factors in the clinical course of HIV-1 infection: chemokines and chemokine receptors

Part 2: Chemokine Receptors as coreceptors for entry of HIV-1

Chapter 7 Adaptation to promiscuous usage of chemokine receptors is not a prerequisite for human immunodeficiency virus type 1 disease progression

Chapter 8 Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1

Chapter 9 In vivo evolution of X4 HIV-1 variants coincides with reduced sensitivity to CXCR4 antagonists

Chapter 10 CCR5 and CXCR4 coreceptor expression levels are associated with HIV-1 disease progression, but not with R5 to X4 virus phenotype evolution

Chapter 11 Persistence of viral HLA-DR- CD4+ T cell reservoir during prolonged treatment of HIV-1 infection with a five-drug regimen

Chapter 12 Both R5 and X4 human immunodeficiency virus type 1 variants persist during prolonged therapy with five antiretroviral drugs

Chapter 13 General Discussion HIV coreceptors: insights in viral tropism and AIDS pathogenesis

Summary

Samenvatting voor niet-ingewijden

List of publications

Dankwoord

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