The role of the phosphatase Pten in T cell development

Authors	T.J. Hagenbeek
Supervisors	H. Spits
Award date	13-05-2008
Number of pages	178
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1 General introduction: Normal and malignant T cell development: the role of PI3K and Notch Chapter 2 The loss of PTEN allows TCR αβ lineage thymocytes to bypass IL-7 and pre-TCR mediated signaling Chapter 3 Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking Chapter 4 T cell lymphomas in T cell-specific Pten-deficient mice originate in the thymus Chapter 5 TCR signaling is required for thymic exit of healthy and malignant Pten-deficient thymocytes Chapter 6 Malignant Pten-deficient thymocytes utilize independent PI3K- and Notch1-mediated signaling for survival and proliferation, and acquire activating NOTCH1 mutations upon loss of γc- and/or (pre-)TCR-mediated signaling Chapter 7 General discussion Summary Samenvatting List of publications Curriculum Vitae Dankwoord Stellingen
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