Germ cell specific gene expression in cancer

Authors	J.W. Bruggeman
Supervisors	A.M.M. van Pelt G. Hamer
Cosupervisors	J.J.B. Koster
Award date	27-02-2024
Number of pages	171
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	We have found that over one thousand genes are exclusively expressed in germ cells and cancer cells, suggesting many shared properties between these cell types. In particular, many genes involved in meiosis are expressed in cancer, likely allowing a cancer cell to repair DNA through semimeiotic recombination. By using the shared properties of cancer and germline cells, we can gain a better understanding of oncogenesis and develop new anticancer therapies that have limited side effects.
Document type	PhD thesis
Note	Please note that the acknowledgements section is not included in the thesis downloads.
Language	English
Downloads	Thesis Front matter Chapter 1: General introduction Chapter 2: Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development Chapter 3: Tumors widely express hundreds of embryonic germline genes Chapter 4: How germline genes promote malignancy in cancer cells Chapter 5: Germline specific genes increase DNA double-strand break repair and radioresistance in lung adenocarcinoma cells Chapter 6: General discussion and implications for future research Chapter 7: Summary; Samenvatting List of co-authors and affiliations; Portfolio
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