Renal perfusion and oxygenation during acute kidney injury

In conclusion, this thesis presents the findings of various experimental therapeutic approaches on in the treatment of acute kidney injury in different experimental models. The findings indicate that the resuscitation fluids commonly used with the idea of protecting the kidney actually do not correct systemic inflammation or oxidative stress, and therefore do not prevent renal ischemia and hypoxia. Nonetheless, even though fluid resuscitation does not have any effects on renal oxygenation, it is of course better than not resuscitating at all. Therefore, optimization of fluid therapy, such as balancing fluids, and other therapeutic approaches aimed to protect the kidney, is utmost important. Taking into account our studies on antioxidants, a new generation of fluids could be developed, incorporating antioxidant properties. However, the long-term effects of balanced and antioxidant-enriched resuscitation on renal function warrants further study.