Seizures in children with acute falciparum malaria : risk factors, mechanisms of neuronal damage and neuro-protection

Thesis

Titlepage

Contents

I. General introduction

II. The incidence, etiology and outcome of acute seizures in children admitted to a rural Kenyan district hospital

III. Haptoglobin HP2-2 genotype, α-thalassaemia and acute seizures in children living in a malaria endemic area of Kenya

IV. Burden, features and outcome of neurological involvement in acute falciparum malaria in Kenyan children

V. Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria

VI. Continuous electroencephalographic monitoring and seizures in children with cerebral malaria

VII. Pathogenesis, clinical features and neurological outcome of cerebral malaria

VIII. Risk factors for persisting neurological and cognitive impairments following cerebral malaria

IX. Axonal and astrocyte injury markers in the cerebrospinal fluid of Kenyan children with severe malaria

X. High plasma levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria

Summary

Samenvatting

Acknowledgments

Curriculum vitae