P-stereogenic wide bite angle diphosphine ligands
| Authors |
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| Publication date | 03-01-2019 |
| Journal | Tetrahedron |
| Volume | Issue number | 75 | 1 |
| Pages (from-to) | 47-56 |
| Number of pages | 10 |
| Organisations |
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| Abstract |
Two modular synthetic approaches for the preparation of novel wide bite angle diphosphine ligands containing stereogenic P-atoms have been developed, leading to compounds (S,S)-2,2′-bis(methylphenylphosphino)diphenyl ether (L1) and (S,S)-2,2′-bis(ferrocenylphenylphosphino)diphenyl ether (L2) in very good diastereomeric ratios. Both protocols involve diphenyl ether as backbone and ,(2RP,4SC,5RC)-(+)-3,4-dimethyl-2,5-diphenyl-1,3,2-oxazaphospholidine borane (RP)-5 as initial auxiliary to induce chirality at phosphorus. The absolute configuration of intermediates (S,S)-9-(BH3)2 and (R,R)-10-(BH3)2 as well as the ligands (S,S)-L1-BH3 and (S,S)-L2 was determined by X-ray crystallographic analysis.
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| Document type | Article |
| Note | With supplementary file |
| Language | English |
| Related dataset | CCDC 1516738: Experimental Crystal Structure Determination CCDC 1516740: Experimental Crystal Structure Determination CCDC 1516737: Experimental Crystal Structure Determination CCDC 1516739: Experimental Crystal Structure Determination |
| Published at | https://doi.org/10.1016/j.tet.2018.10.070 |
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