Synthesis of water-soluble scaffolds for peptide cyclization, labeling, and ligation
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| Publication date | 2012 |
| Journal | Organic Letters |
| Volume | Issue number | 14 | 5 |
| Pages (from-to) | 1194-1197 |
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| Abstract | The synthesis and applications of water-soluble scaffolds that conformationally constrain side chain unprotected linear peptides containing two cysteines are described. These scaffolds contain a functionality with orthogonal reactivity to be used for labeling and ligation. This is illustrated by the chemical ligation of two dissimilar constrained peptides via oxime ligation or strain-promoted azide-alkyne cycloaddition in aqueous media |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1021/ol203259a
(Final published version)
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