Reading the maps: Organization and function of chromatin types in Drosophila

Authors	U. Braunschweig
Supervisors	M.M.S. van Lohuizen
Cosupervisors	B. van Steensel
Award date	04-11-2010
ISBN	9789075575323
Number of pages	161
Publisher	Amsterdam: Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	The work presented in this thesis shows that the Drosophila genome is organized in chromatin domains with many implications for gene regulation, nuclear organization, and evolution. Furthermore it provides examples of how maps of chromatin protein binding, combined with computational approaches, can yield valuable insights into chromatin organization and function.
Document type	PhD thesis
Language	English
Downloads	Thesis Front cover Title pages Table of contents General introduction Chapter 1: Histone H1 binding is inhibited by histone variant H3.3 Chapter 2: Global chromatin domain organization of the Drosophila genome Chapter 3: Bayesian network analysis of targeting interactions in chromatin Chapter 4: Systematic protein location mapping reveals five principal chromatin types in Drosophila cells General discussion List of abbreviations Summary / Samenvatting (Nederlands) Curriculum vitae List of publications Acknowledgements Supplementary data
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