Towards a Complex Automata multiscale model of in-stent restenosis

Authors
  • A. Caiazzo
  • D. Evans
  • J.-L. Falcone
  • J. Hegewald
Publication date 2009
Host editors
  • G. Allen
  • J. Nabrzyski
  • E. Seidel
  • G.D. van Albada
  • J. Dongarra
  • P.M.A. Sloot
Book title Computational Science – ICCS 2009
Book subtitle 9th International Conference Baton Rouge, LA, USA, May 25-27, 2009 : proceedings
ISBN
  • 9783642019692
ISBN (electronic)
  • 9783642019708
Series Lecture Notes in Computer Science
Event International Conference on Computational Science 2009 (ICCS 2009), Baton Rouge, LA, USA
Volume | Issue number I
Pages (from-to) 705-714
Publisher Berlin: Springer
Organisations
  • Faculty of Science (FNWI) - Informatics Institute (IVI)
Abstract
In-stent restenosis, the maladaptive response of a blood vessel to injury caused by the deployment of a stent, is a multiscale problem involving a large number of processes. We describe a Complex Automata Model for in-stent restenosis, coupling a bulk flow, drug diffusion, and smooth muscle cell model, all operating on different time scales. Details of the single scale models and of the coupling interfaces are described, together with first simulation results, obtained with a dedicated software environment for Complex Automata simulations. The results show that the model can reproduce growth trends observed in experimental studies.
Document type Conference contribution
Language English
Published at https://doi.org/10.1007/978-3-642-01970-8_70
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