Coagulation and fibrinolysis in tuberculosis, melioidosis and beyond

The studies presented in this thesis significantly contribute to the current knowledge on the role of proteins involved in coagulation, anticoagulation and fibrinolysis during TB and melioidosis. We showed that during TB, although a chronic disease, the coagulation system becomes activated. The physiological significance of this activation, however, still is unclear and we failed to show a clear functional role for proteins involved in the PC system. With respect to melioidosis, we here demonstrated that some (components of) proteins involved in coagulation and fibrinolysis significantly contribute to the host defense against B. pseudomallei. This knowledge may add to further understanding of the pathophysiological processes during this severe septic disease and may serve as new targets for additional therapies.