The influence of hyperglycemia and hyperinsulinemia on innate immune and coagulent responses

Authors	M.E. Stegenga
Supervisors	T. van der Poll H.P. Sauerwein
Award date	30-05-2008
ISBN	9789064642555
Number of pages	151
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Titlepage Contents Chapter 1: Introduction and outline of the thesis Chapter 2: Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans Chapter 3: Effect of acute hyperglycemia and/or hyperinsulinemia on proinflammatory gene expression, cytokine production and neutrophil function in humans Chapter 4: Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia Chapter 5: Leptin and host defense against gram-positive and gramnegative pneumonia in mice Chapter 6: The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice Chapter 7: A single dose of rosiglitazone reduces neutrophil activation and cytokine release in human volunteers Chapter 8: Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis Chapter 9: Summary and general discussion Samenvatting Dankwoord Curriculum Vitae
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