Ras family GTPase signaling contributions to inflammation and joint destruction in rheumatoid arthritis

Authors	C.T.D. de Launaij
Supervisors	P.P. Tak
Cosupervisors	K.A. Reedquist
Award date	11-03-2010
ISBN	9789090251011
Number of pages	233
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Titlepage Content chapter 1 / General introduction chapter 2 / The Ras guanine nucleotide exchange factor RasGRF1 promotes MMP-3 production in rheumatoid arthritis synovial tissue chapter 3 / Silencing expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis chapter 4 / Phosphorylation of extracellular signal regulated kinases 1 and 2 is specifically associated with angiogenic Tie2 expression in the synovium of patients with active rheumatoid arthritis but not psoriatic arthritis chapter 5 / Selective involvement of ERK and JNK Mitogen-Activated Protein Kinases in early rheumatoid arthritis chapter 6 / Inhibition of FoxO Family Member transcription factors in rheumatoid synovial tissue chapter 7 / Angiopoietins-1 and -2 make distinct contributions to synovial Tie2 engagement in patients with rheumatoid arthritis and psoriatic arthritis chapter 8 / Summary and general discussion Nederlandse samenvatting Dankwoord Curriculum Vitea Bibliography Color figures
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