Development of new imaging techniques for improved detection and characterization of focal liver lesions using magnetic resonance imaging

Thesis

Cover

Title pages

Table of contents

Chapter 1: General introduction and outline of the thesis

Chapter 2: Comparison of respiratory-triggered T2-weighted turbo spin-echo imaging versus breath-hold T2-weighted turbo spin-echo imaging in focal liver lesion detection and characterization

Chapter 3: Improved focal liver lesion detection : comparison of single shot diffusion-weighted echo planar and single shot T2w turbo spin echo techniques

Chapter 4: Evaluation of true diffusion, perfusion factor, and apparent diffusion coefficient in non-necrotic liver metastases and uncomplicated liver hemangiomas using black-blood echo planar imaging

Chapter 5: Improved focal liver lesion detection : comparison of single-shot spin-echo echo-planar and superparamagnetic iron oxide (SPIO)-enhanced MRI

Chapter 6: Comparison of MRI (including SS SE-EPI and SPIO-enhanced MRI) and FDG-PET/CT for the detection of colorectal liver metastases

Chapter 7: Focal liver lesion detection and characterization : comparison of non-contrast-enhanced and SPIO-enhanced diffusion-weighted single-shot spin echo echo planar and turbo spin echo T2-weighted imaging

Chapter 8: Perfusion MRI of the whole liver at high temporal and spatial resolution with 4D THRIVE : feasibility of focal lesion characterization using parametric maps

Chapter 9: Surface functionalization of magnetoliposomes in view of improving iron oxide-based magnetic resonance imaging contrast agents : anchoring of gadolinium ions to a lipophilic chelate

Chapter 10: Evaluation of peri-tumoural vessels surrounding colorectal liver metastases after intravenous injection of magnetoliposomes in rats : correlation with 3T MRI and histopathology

Summary and conclusions

Samenvatting en conclusies

List of abbreviations

List of publications

Dankwoord en curriculum vitae