T cell turnover and thymic function in HIV-1 infection

Thesis

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Titlepage

Contents

1 Prologue

Part 1 Peripheral T cell turnover

2 Introduction

3 Increased T cell turnover in HIV-1 infection is mainly due to chronic immune activation: a longitudinal analysis in patients before and during highly active anti-retroviral therapy (HAART)

4 Discordant responses during antiretroviral therapy: role for immune activation and T cell redistribution rather than true CD4 T cell loss

5 Persistent immune activation in HIV-1 infection is associated with naïve T cell depletion and progression to AIDS

Part 2 Thymic function

6 Introduction: Tilted balacne of a T cell renewal in HIV-1 infection

7 Increased cell division but not thymic dysfunction rapidly affects the T cell receptor excision circle content of the naïve T cell population in HIV-1 infection

8 T cell receptor excision circles (TRECs) as markers for recent thymic emigrants. Basic aspects, technical approach, and guidelines for interpretation

9 T cell dynamics in HIV-1 infected children: a longitudinal study on TRECs, T cell numbers and peripheral T cell division before and during antiretroviral therapy

10 Depletion of naive CD4+ T cells by syncytium inducing, CXCR4 using HIV-1 variants occurs mainly through increased peripheral T cell death rather than thymic dysfunction

11 T cell receptor excision circle (TREC) and T cell dynamics after allogeneic stem cell transplantation are related to clinical events

12 T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock

13 Epilogue

Summary

Samenvatting voor niet-ingewijden

Co-authors' affiliations

Curriculum vitae

Publications

Dankwoord

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