| Abstract |
Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are chronic cholestatic liver diseases of unknown etiology. True population-based epidemiological studies are scarce, especially in PSC. There is a need for large population-based studies combining meticulous case-finding and case-ascertainment strategies, which may provide clues as to possible pathogenesis and environmental risk factors for these rare enigmatic diseases. This thesis describes studies on the two largest population-based cohorts of PSC and PBC patients worldwide.
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