Innovative imaging techniques for improved characterization of atherosclerosis and the assessment of novel therapies

Thesis

Front cover

Stellingen

Title pages

Table of contents

Chapter 1: General introduction and outline of the thesis

Chapter 2: Surrogate markers in clinical trials: Challenges and opportunities

Chapter 3: Atherosclerosis imaging as a benchmark in the development of novel cardiovasular drugs

Chapter 4: Ultrasound protocols to measure carotid intima-media thickness in trials: Comparison of reproducibility, rate of progression, and effect of intervention in subjects with familial hypercholesterolemia and subjects with mixed dyslipidemia

Chapter 5: Simvastatin with or without ezetimibe in familial hypercholesterolemia

Chapter 6: ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: The CAPTIVATE randomized trial

Chapter 7: Vascular wall imaging by MRI

Chapter 8: Comparison of in vivo carotid 3.0-T magnetic resonance to B-mode ultrasound imaging and histology in a porcine model

Chapter 9: In vivo quantification of carotid artery wall dimensions: 3.0-Tesla MRI versus B-mode ultrasound imaging

Chapter 10: Carriers of lecithin:cholesterol acyltransferase gene mutations have accelerated atherogenesis as assessed by carotid 3.0-T magnetic resonance imaging

Chapter 11: ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden

Chapter 12: Detection of liquid phase cholesteryl ester in carotid atherosclerotic lesions by 1H-magnetic resonance spectroscopy in humans

Chapter 13: Endothelial shear stress: A critical determinant of arterial remodeling and arterial stiffness in humans: A carotid 3.0-T MRI study

Chapter 14: Postprandial hypertriglyceridemia decreases carotid endothelial shear stress measured by 3.0-T MRI

Chapter 15: Prevalence and risk factors of carotid vessel wall inflammation in coronary artery disease patients: FDG-PET and CT imaging study

Chapter 16: Serum inflammatory biomarkers and plaque inflammation assessed by 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the dal-PLAQUE study

Chapter 17: A statin-loaded reconstituted high-density lipoprotein nanoparticle as a targeted therapy for atherosclerotic plaque inflammation

Chapter 18: General discussion and summary

Nederlandse samenvatting

Curriculum vitae

Publications

Dankwoord