Novel Mechanisms and Functions for Hedgehog Signaling in Development and Disease

Authors	M.F. Bijlsma
Supervisors	M.P. Peppelenbosch
Cosupervisors	C.A. Spek
Award date	19-09-2008
ISBN	9789064642821
Number of pages	107
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Cover Titlepage Contents Preface Part I: Novel Mechanisms for Hedgehog Signaling. Chapter 1: Hedgehog: an Introduction to an Unusual Signal Transducer Chapter 2: Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion Chapter 3: Inhibition of Hedgehog-dependent Cancer Cell Growth by Vitamin D3 Chapter 4: Sonic Hedgehog Induces Transcription-Independent Cytoskeletal Rearrangement and Migration Regulated by Arachidonate Metabolites Chapter 5: Leukotriene Synthesis Is Required for Hedgehog-Dependent Neurite Projection in Neuralized Embryoid Bodies but not for Motor Neuron Differentiation Chapter 6: Establishment and Characterization of Immortalized Gli Null Mouse Embryonic Fibroblast Cell Lines Part 2: Novel Functions for Hedgehog Signaling. Chapter 7: Hedgehog Morphogen in Cardiovascular Disease Chapter 8: Endogenous Hedgehog Expression Contributes to Myocardial Ischemia Reperfusion-Induced Injury Chapter 9: Hypoxia Induces a Hedgehog Response Mediated by HIF-1a Chapter 10: Summary and Discussion Nederlandse Samenvatting Author Affiliations List of Publications Dankwoord / Acknowledgements Curriculum Vitae
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