Bridging the gap Proteomics as a complementary tool in forensics

This thesis explores the potential of mass spectrometry (MS)-based proteomics as a complementary tool in forensic science, with the overarching aim of maximizing the information that can be obtained from biological traces. Over the past two decades, proteomics has steadily evolved, offering new opportunities to enhance forensic investigations. Through a series of studies, this thesis evaluates the applicability of proteomics across key areas of forensic analysis, including phenotyping, source attribution, timeline and event reconstruction. The findings demonstrate that protein-based approaches can provide valuable insights beyond traditional methods, particularly in identifying the origin of biological material and improving the interpretation of complex biological traces.
Overall, the work presented in this thesis highlights both the promise of MS-based proteomics and the current hurdles that must be overcome for its implementation in routine forensic analysis.