ABC transporter compound knockout mice : physiological and pharmacological characterization

Thesis

Cover

Title pages

Table of contents

Chapter 1: Compound transporter knockout mice : powerful tools to unravel the pharmacological and physiological functions of ATP binding cassette drug transporters

Chapter 2: Carcinogen and anti-cancer drug transport by Mrp2 in vivo : studies using Mrp2 (Abcc2) knockout mice

Chapter 3: Multidrug resistance protein 2 (Mrp2; Abcc2) is an important determinant of paclitaxel pharmacokinetics

Chapter 4: Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate

Chapter 5: Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo

Chapter 6: Abcc2 (Mrp2), Abcc3 (Mrp3) and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo

Chapter 7: Impact of Abcc2 (Mrp2), Abcc3 (Mrp3) and Abcg2 (Bcrp1) on the oral pharmacokinetics of the anti-cancer drug methotrexate and its main metabolite 7-hydroxymethotrexate in mice

Chapter 8: Impact of ABC transporters on the disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine) and its mutagenic metabolites in vivo

Chapter 9: Physiological and pharmacological roles of ABCG2 (BCRP) : recent findings in Abcg2 knockout mice

Chapter 10: Impact of Abcg2 (Bcrp1) expression in mother and pup on riboflavin levels in suckling pups

Summary

Samenvatting

Abbreviations

List of publications

Curriculum vitae

Dankwoord