Embedding trials in evidence-based clinical practice

This thesis presents a number of research projects centred on ‘evidence-based medicine’. It consists of two parts. Part 1 focuses on improving recruitment of the necessary number of patients in clinical trials, as this is the major problem while evaluating the effectiveness of interventions in health care. To improve our understanding of patient recruitment we tried to identify obstacles and facilitators for successful recruitment. Part 2 focuses on improving integration of evidence-based decision making in clinical practice. We identified barriers for EBM teaching in practice, developed an EBM Teach the Teacher course, and evaluated methods to assess EBM in clinical practice.