Characterization of the mouse and human breast cancer genome

Authors	H. Holstege
Supervisors	A.J.M. Berns
Cosupervisors	J.M.M. Jonkers
Award date	10-02-2010
ISBN	9789461080110
Number of pages	213
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1. General Introduction Chapter 2. Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data Chapter 3. Exploring genomic gains and losses selected for during development of BRCA1-and BRCA2-related breast tumors Chapter 4. High incidence of protein-truncating TP53 mutations in BRCA1- related breast cancer Chapter 5. BRCA1-mutated and basal-like breast cancers share molecular characteristics Chapter 6. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer Chapter 7. Comparative oncogenomics of BRCA1- and BRCA2-mutated human breast cancers and mouse mammary tumors English Summary Nederlandse Samenvatting Curriculum Vitae and publications Acknowledgements
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