Modulation of pyrimidine nucleotide synthesis in pediatric leukemia: the pivotal role of CTP synthetase

Thesis

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Titlepage

CONTENTS

List of abbreviations

Chapter 1 INTRODUCTION

Chapter 2 CYTIDINE TRIPHOSPHATE SYNTHETASE ACTIVITY AND mRNA EXPRESSION IN NORMAL HUMAN BLOOD CELLS

Chapter 3 INCREASED ACTIVITY OF CYTIDINE TRIPHOSPHATE SYNTHETASE IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA

Chapter 4 IN VITRO INHIBITION OF CYTIDINE TRIPHOSPHATE SYNTHETASE ACTIVITY BY CYCLOPENTENYL CYTOSINE IN PAEDIATRIC ACUTE LYMPHOCYTIC LEUKAEMIA

Chapter 5 CYCLOPENTENYL CYTOSINE INHIBITS CYTIDINE TRIPHOSPHATE SYNTHETASE IN PAEDIATRIC ACUTE NONLYMPHOCYTIC LEUKAEMIA: A PROMISING TARGET FOR CHEMOTHERAPY.

Chapter 6 CYCLOPENTENYL CYTOSINE INCREASES THE PHOSPHORYLATION AND INCORPORATION INTO DNA OF 1-ß-D-ARABINOFURANOSYL CYTOSINE IN A HUMAN T-LYMPHOBLASTIC CELL-LINE

Chapter 7 CYCLOPENTENYL CYTOSINE INDUCES APOPTOSIS AND INCREASES CYTARABINE-INDUCED APOPTOSIS IN A T-LYMPHOBLASTIC LEUKEMIC CELL-LINE

Chapter 8 CYCLOPENTENYL CYTOSINE ENHANCES THE CYTOTOXICITY OF ARABINOFURANOSYL CYTOSINE IN ACUTE MYELOID LEUKEMIA

Chapter 9 INCREASED PHOSPHORYLATION OF ARABINOFURANOSYL CYTOSINE BY CYCLOPENTENYL CYTOSINE IN PAEDIATRIC ACUTE LYMPHOCYTIC LEUKAEMIA (PRELIMINARY RESULTS)

Chapter 10 DISCUSSION AND RECOMMENDATIONS

SUMMARY FOR THE UNINITIATED

SAMENVATTING VOOR DE LEEK

NAWOORD

CURRICULUM VITAE

PUBLICATIONS

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