Gene expression in chromosomal Ridge domains : influence on transcription, mRNA stability, codon usage, and evolution

Authors	H.J. Gierman
Supervisors	R. Versteeg
Award date	27-04-2010
ISBN	9789090253053
Number of pages	168
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	Chromosomes are the long DNA molecules that carry the genetic code of our genes. Each gene encodes a protein, but also contains the information that controls the activity of that gene. In this thesis, we find that chromosomal domains with many active genes (so-called 'Ridges'), also control gene activity. Our results imply that Ridges facilitate the high activity of important genes. Ridges might thus provide an alternative mechanism for changes in gene activity during human evolution.
Document type	PhD thesis
Language	English
Downloads	Thesis Front cover Title pages Contents 1: Introduction : gene regulation by chromosomal domains 2: Domain-wide regulation of gene expression in the human genome 3: Genes in chromosomal Ridge domains have increased mRNA folding stability and half-life, further contributing to their high expression 4: A model to explain natural selection for extreme levels of protein expression in the human genome 5: EZH2 overexpression associated with gain of chromosome arm 7q is essential for neuroblastoma cell cycle progression and a marker of poor prognosis 6: Discussion : mechanism of Ridges and implications for evolution 7: Summary 8: Nederlandse samenvatting 9: Dankwoord 10: Curriculum vitae 11: List of publications Back cover Stellingen
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