Identification and characterization of the t(w73) candidate gene Ortc3

Authors	S.F.M.J. Verhaagh
Supervisors	A.J.M. Berns
Cosupervisors	D.P. Barlow
Award date	08-06-2001
Number of pages	117
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Note	Research conducted at: NKI
Language	English
Downloads	Thesis Cover Titlepage Contents Chapter 1 Mutations that affect the development and function of the extraembryonic membranes and placenta Chapter 2 Cloning of the mouse and human solute carrier 22a3 (SIc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27 Chapter 3 Genetic analysis of the organic cation transporter genes Orct2/SIc22a2 and Orct3/SIc22a3 reduces the critical region for the t haplotype mutant tw73 to 200 kb Chapter 4 The extraneuronal monoamine transporter SIc22a3/Orct3 co-localizes with the Maoa metabolizing enzyme in mouse placenta Chapter 5 Impaired activity of the extraneuronal monoamine transporter system known as uptake2 in Orct3/SIc22a3 deficient mice Chapter 6 Summarizing discussion Nederlandse samenvatting Dankwoord Curriculum Vitae List of publications Abbreviations Cover
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