Improving cardiovascular disease prevention : from risk assessment to novel therapy

Thesis

Cover

Titlepage

Contents

Chapter 1 General introduction & Outline of the thesis

Part I Risk Assessment & Treatment

Chapter 2 Value of LDL particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study

Chapter 3 HDL cholesterol, HDL particle size and apolipoprotein A-I; significance for cardiovascular disease risk: the IDEAL and EPIC-Norfolk studies

Chapter 4 Role of the apolipoprotein B/A-I ratio in cardiovascular risk assessment: a case control analysis in EPIC-Norfolk

Chapter 5 Lipids, apolipoproteins and their ratios in relation to cardiovascular events on statin treatment: pooled analyses of the TNT and IDEAL trials

Chapter 6 Target values for lipids, apolipoproteins and their ratios in patients receiving intensive statin therapy: post-hoc analysis of the IDEAL study

Part II Novel Therapy

Chapter 7 Inherited disorders of HDL metabolism and atherosclerosis

Chapter 8 Cholesteryl ester transfer protein and hyperalphalipoproteinemia

Chapter 9 Relationship between the CETP -629C->A polymorphism and risk for coronary artery disease in the EPIC-Norfolk population study

Chapter 10 CETP inhibition beyond raising HDL cholesterol levels: pathways by which modulation of CETP activity may alter atherogenesis

Chapter 11 Summary and Conclusions / Samenvatting en Conclusies

List of publications / Dankwoord