Communication: Nanosecond folding dynamics of an alpha helix: Time-dependent 2D-IR cross peaks observed using polarization-sensitive dispersed pump-probe spectroscopy
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| Publication date | 28-01-2015 |
| Journal | Journal of Chemical Physics |
| Article number | 041103 |
| Volume | Issue number | 142 | 4 |
| Number of pages | 5 |
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| Abstract | We present a simple method to measure the dynamics of cross peaks in time-resolved two-dimensional vibrational spectroscopy. By combining suitably weighted dispersed pump-probe spectra, we eliminate the diagonal contribution to the 2D-IR response, so that the dispersed pump-probe signal contains the projection of only the cross peaks onto one of the axes of the 2D-IR spectrum. We apply the method to investigate the folding dynamics of an alpha-helical peptide in a temperature-jump experiment and find characteristic folding and unfolding time constants of 260 ± 30 and 580 ± 70 ns at 298 K. |
| Document type | Article |
| Note | © 2015 AIP Publishing LLC. - With supplementary file. |
| Language | English |
| Published at | https://doi.org/10.1063/1.4906456 |
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Communication - Nanosecond folding dynamics of an alpha helix
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