Artemether-lumefantrine: a new treatment combination for multi-drug resistant falciparum malaria

Thesis

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Titlepage

Contents

Introduction

Chapter 1: The treatment of chloroquine-resistant malaria.

Chapter 2: Artesunate versus artemether for the treatment of recrudescent multi-drug resistant falciparum malaria.

Chapter 3: Randomized comparison of artemether-benflumetol and artesunate-mefloquine in the treatment of multidrug resistant falciparum malaria.

Chapter 4: The clinical pharmacokinetics and pharmacodynamics of artemether-lumefantrine.

Chapter 5: Efficacy of six doses of artemether-lumefantrine (benflumetol) in the treatment of multi-drug resistant falciparum malaria.

Chapter 6: The pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria.

Chapter 7: The relationship between capillary and venous concentrations of the antimalarial drug lumefantrine (benflumetol).

Chapter 8: Efficacy of the six dose artemether-lumefantrine regimen, given over three days, in the treatment of multi-drug resistant falciparum malaria.

Chapter 9: A case control auditory evaluation of patients treated with artemisinin derivatives for multidrug resistant falciparum malaria.

Chapter 10: No cardiotoxicity with high dose lumefantrine.

Chapter 11: Discussion

Summary of chapters

Samenvatting

Acknowledgements

Curriculum vitae

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