[131 I]Meta-iodobenzylguanidine ([131 I] MIBG) related thrombocytopenia

Thesis

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Titlepage

CONTENTS

LIST OF ABBREVIATIONS

Chapter 1 Introduction

Chapter 2 Uptake of the neuron-blocking agent meta-iodobenzylguanidine and serotonin by human platelets and neuro-adrenergic tumour cells

Chapter 2 Uptake of the neuron-blocking agent metaiodobenzylguanidine and serotonin by human platelets and neuro-adrenergic tumour cells

Chapter 3 Meta-iodobenzylguanidine uptake in platelets, megakaryoblastic leukemia cell lines MKPL-1 and CHRF-288-11, and erythroleukemic cell line Hel

Chapter 4 Blocking of [131I] meta-iodobenzylguanidine (MIBG) uptake in human platelets by selective serotonin uptake inhibitors without reducing its accumulation in SK-N-SH neuroblastoma xenografts.

Chapter 5 Human megakaryocytes cultured in vitro accumulate serotonin but not meta-iodobenzylguanidine (MIBG) whereas platelets concentrate both.

Chapter 6 Megakaryocytes and platelets both express the serotonin transporter (SERT) and the vesicular monoamine transporter 2 (VMAT2), but differ highly in MIBG accumulating capacities

General Summary and Discussion

Samenvatting voor de leek

APPENDIX

Dankwoord

CURRICULUM VITAE

PUBLICATIONS

Stellingen bij het proefschrift van G.A.M. Tytgat

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