Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective

Open Access
Authors
  • A. ten Brinke
  • M. Martinez-Llordella
  • N. Cools
  • C.M.U. Hilkens
  • S.M. van Ham ORCID logo
  • B. Sawitzki
  • E.K. Geissler
  • G. Lombardi
  • P. Trzonkowski
  • Eva Martinez-Caceres
Publication date 22-02-2019
Journal Frontiers in Immunology
Article number 181
Volume | Issue number 10
Number of pages 20
Organisations
  • Faculty of Science (FNWI) - Swammerdam Institute for Life Sciences (SILS)
Abstract Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.
Document type Review article
Language English
Published at https://doi.org/10.3389/fimmu.2019.00181
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