KLF2, a critical modulator in vascular disease

Authors	J.V. van Thienen
Supervisors	H. Pannekoek A.J.G. Horrevoets
Award date	27-01-2009
ISBN	9789090238333
Number of pages	185
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Title pages Contents Chapter 1: Introduction Chapter 2: Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes Chapter 3: Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization Chapter 4: Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2 Chapter 5: Endothelial KLF2 regulates mitogen activated protein kinase signaling through RhoA and the actin cytoskeleton Chapter 6: Involvement of KLF2 in endothelial regeneration : a novel target for prevention of in-stent thrombosis and restenosis Chapter 7: Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2 Chapter 8: Incomplete suppression of macrophage inflammatory response by KLF2 aggravates atherosclerosis Chapter 9: General discussion Chapter 10: Summary en samenvatting Dankwoord Publicatielijst Curriculum vitae
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