HIV-1 infection in macrophages and genes involved throughout: Big eaters versus small invaders

Authors	V. Cobos Jiménez
Supervisors	T.B.H. Geijtenbeek
Cosupervisors	N.A. Kootstra
Award date	25-03-2014
ISBN	9789461824127
Number of pages	171
Organisations	Faculty of Medicine (AMC-UvA)
Abstract	In this thesis we have studied the infectious process of HIV-1 in differently polarized macrophages. The purpose of this research was to identify cellular factors that are involved in HIV-1 infection of macrophages, how these factors affect viral replication and whether their function or expression is affected by stimulatory signals that macrophages encounter during their differentiation in the tissues.
Document type	PhD thesis
Note	Research conducted at: Universiteit van Amsterdam
Language	English
Downloads	Thesis Front cover Title pages Table of contents Chapter 1: General introduction Chapter 2: Next-generation sequencing of microRNAs uncovers expression signatures in polarized macrophages Chapter 3: Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons Chapter 4: Single-strand RNA endonuclease G3BP1 restricts HIV-1 replication in macrophages and T cells Chapter 5: PDE8A supports HIV-1 replication in macrophages at the level of reverse transcription Chapter 6: CCR5-using HIV-1 induces an anti-inflammatory profile in primary macrophages Chapter 7: General discussion Summary Samenvatting Resumen Curriculum vitae Publications Ph.D. portfolio Acknowledgements
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