The role of glycosphingolipids in insulin signaling and lipid metabolism

Authors	N. Bijl
Supervisors	J.M.F.G. Aerts A.K. Groen
Cosupervisors	R.G. Boot
Award date	24-11-2009
Number of pages	199
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Title pages Contents Chapter 1: Introduction Chapter 2: Improved glycemic control in obese rodents by combined pharmacological reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation Chapter 3: Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation Chapter 4: Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice Chapter 5: Treatment of genetically obese (ob/ob) mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin (AMP-DNM) increases fat oxidation and decreases food intake Chapter 6: The glucosylceramide synthase inhibitor AMP-DNM induces SREBP regulated gene expression and cholesterol synthesis in HepG2 cells Chapter 7: Reduction of glycosphingolipid biosynthesis stimulates biliary lipid secretion in mice Chapter 8: Bile acids and their role in cholesterol homeostasis Chapter 9: Summary and discussion Samenvatting Dankwoord
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