Total syntheses of mitragynine, paynantheine and speciogynine via an enantioselective thiourea-catalysed Pictet-Spengler reaction
| Authors |
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| Publication date | 2012 |
| Journal | Chemical Communications |
| Volume | Issue number | 48 | 100 |
| Pages (from-to) | 12243-12245 |
| Organisations |
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| Abstract |
The pharmacologically interesting indole alkaloids (-)-mitragynine, (+)-paynantheine and (+)-speciogynine were synthesised in nine steps from 4-methoxytryptamine by a route featuring (i) an enantioselective thiourea-catalysed Pictet-Spengler reaction, providing the tetrahydro-β-carboline ring and (ii) a Pd-catalysed Tsuji-Trost allylic alkylation, closing the D-ring. |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1039/c2cc37023a
(Final published version)
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