Probe pressure effects on Multi-Diameter Single Fiber Reflectance spectroscopy measurements

Multi-Diameter Single Fiber Reflectance spectroscopy (MDSFR) allows rapid and noninvasive extraction of tissue optical properties which requires the fiberoptic fiber to be placed in contact with the tissue. To ensure a good optical contact, the application of probe pressure is inevitable and usually not well controlled. This thesis focuses on investigating the effects of probe pressure on Multi-Diameter Single Fiber Reflectance spectroscopy measurements and studying the underlying mechanisms of the pressure-induced optical property changes. Furthermore, our research involves further improvement of both the measurement approach and the data-analyzing model, leading to exploitation of new functionality.