Epidemiology and clinical aspects of sudden cardiac death in the young

Thesis

Cover

Title pages

Contents

1: Outline of the thesis

2: Sudden death in the young: What do we know about it and how to prevent?

3: Rationale and design of the CAREFUL study: The yield of cardiogenetic screening in first degree relatives of sudden cardiac and unexplained death victims <45 years

4: Improving usual care after sudden death in the young with focus on inherited cardiac diseases (the CAREFUL study): A community-based intervention study

5: Erfelijkheidsonderzoek bij plotselinge dood van jonge personen: Waar zitten de problemen?

6: Experiences, considerations and emotions relating to cardiogenetic evaluation in relatives of young sudden cardiac death victims

7: Incidence, causes and outcome of out-of-hospital cardiac arrest in children: A comprehensive, prospective, population-based study in the Netherlands

8: Diagnostic yield in sudden unexplained death and aborted cardiac arrest in the young: The experience of a tertiary referral center in the Netherlands

9: Are individuals within families with truly unexplained premature sudden death at risk during long-term follow-up?

10: Catecholaminergic polymorphic ventricular tachycardia: From bench to bedside

11: Familial evaluation in catecholaminergic polymorphic ventricular tachycardia: Disease penetrance and expression in cardiac ryanodine receptor mutation-carrying relatives

12: Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia

13: Effects of flecainide on exercise-induced ventricular arrhythmias and in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia

14: Derivation and validation of a simple exercise-based algorithm for prediction of genetic testing in relatives of long-QT syndrome probands

15: The phenomenon of “QT stunning”: The abnormal QT prolongation provoked by standing persists even as the heart rate returns to normal in patients with long-QT syndrome

16: Summary

17: Samenvatting

Biography

List of publications

Acknowledgements / dankwoord

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