Function and regulation of the histone methyltransferase Dot1

Authors	F. Frederiks
Supervisors	M.M.S. van Lohuizen
Cosupervisors	F. van Leeuwen
Award date	29-10-2010
Number of pages	182
Organisations	Faculty of Medicine (AMC-UvA)
Document type	PhD thesis
Language	English
Downloads	Thesis Cover Title pages Table of contents Chapter 1: Introduction and general discussion Chapter 2: Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core Chapter 3: Non‐processive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states Chapter 4: Progressive methylation of aging histones by Dot1 results in an epigenetic clock Chapter 5: Heterologous expression reveals distinct enzymatic activities of two Dot1 histone methyltransferases of Trypanosoma brucei Chapter 6: Two Dot1 isoforms in Saccharomyces cerevisiae as a result of leaky scanning by the ribosome Chapter 7: Characterization of the role of Dot1 in the UV‐ induced DNA damage response in budding yeast Summary Samenvatting List of publications Dankwoord
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