Dehydrogenative Azolation of Arenes in a Microflow Electrochemical Reactor
| Authors |
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| Publication date | 19-11-2021 |
| Journal | Journal of Organic Chemistry |
| Volume | Issue number | 86 | 22 |
| Pages (from-to) | 16195-16203 |
| Number of pages | 9 |
| Organisations |
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| Abstract | The electrochemical synthesis of aryl azoles was performed for the first time in a microflow reactor. The reaction relies on the anodic oxidation of the arene partners making these substrates susceptible for C-H functionalization with azoles, thus requiring no homogeneous transition-metal-based catalysts. The synthetic protocol benefits from the implementation of a microflow setup, leading to shorter residence times (10 min), compared to previously reported batch systems. Various azolated compounds (22 examples) are obtained in good to excellent yields. |
| Document type | Article |
| Note | With supplementary file. |
| Language | English |
| Published at | https://doi.org/10.1021/acs.joc.1c01409 |
| Downloads |
acs.joc.1c01409
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