Circulatory effects of electrical stimulation of the carotid sinus nerves in man: A physiological study

The aims of this investigation were 1) to study the time course of the reflex circulatory changes evoked by carotid sinus nerves (CSN) stimulation in unsedated man (chapters IV - VII), and 2) to establish the optimal frequency of CSN stimulation for the relief of angina pectoris (chapters VIII and IX). The results concern eleven subjects with coronary heart disease and three hypertensive subjects.
In conclusion, in a limited number of unsedated subjects with coronary heart disease CSN stimulation in rest provided an unique opportunity to study the time course of circulatory changes evoked reflexly by the abrupt increase or decrease of the number of baroreceptor afferent impulses. The results support the suggestion that anesthesia and tissue trauma modify central processing of baroreceptor information to such an extent that quantitative data on baroreflex regulation of the circulation are not applicable to unsedated man if derived in acute experiments on the anesthetized animal.