The 'Triple Study': viral dynamics and immune reconstition in HIV-1 infection during potent antiretroviral therapy

Thesis

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Titlepage

TABLE OF CONTENTS

CHAPTER I INTRODUCTION

CHAPTER II DECREASE OF HIV-1 RNA LEVELS IN LYMPHOID TISSUE AND PERIPHERAL BLOOD DURING TREATMENT WITH RITONAVIR, LAMIVUDINE AND ZIDOVUDINE

CHAPTER III KINETICS OF RESPONSE TO ANTIVIRAL COMBINATION THERAPY OF HIV-1 INFECTION IN LYMPHOID TISSUE

CHAPTER IV RATE OF HIV-1 DECLINE FOLLOWING ANTIRETROVIRAL THERAPY IS RELATED TO VIRAL LOAD AT BASELINE AND DRUG REGIMEN

CHAPTER V BIPHASIC KINETICS OF PERIPHERAL BLOOD T CELLS AFTER TRIPLE COMBINATION THERAPY IN HIV-1 INFECTION: A COMPOSITE OF REDISTRIBUTION AND PROLIFERATION

CHAPTER VI KINETICS OF CD4+ T CELL REPOPULATION IN LYMPHOID TISSUES AFTER TREATMENT OF HIV-1 INFECTION

CHAPTER VII IMMUNE RECONSTITUTION AFTER TWO YEARS OF SUCCESSFUL POTENT ANTIRETROVIRAL THERAPY IN PREVIOUSLY UNTREATED HIV-1 INFECTED ADULTS

CHAPTER VIII EVALUATION OF A SECOND GENERATION NASBA-BASED ASSAY FOR QUANTIFICATION OF HIV-1 RNA: COMPARISON TO PCR-BASED AND SIGNAL AMPLIFICATION BASED ASSAYS AND USE OF ULTRASENSITIVE PROTOCOL ADAPTATIONS

CHAPTER IX BOTH ANTI-HIV-1 SPECIFIC AND TOTAL ANTIBODY LEVELS DECLINE IN RESPONSE TO SUPPRESSION OF VIREMIA WITH ANTIRETROVIRAL THERAPY AND ARE PARALLELED BY CHANGES IN CIRCULATING CD8+ MEMORY T CELLS

CHAPTER X DISCUSSION AND CONCLUSION

CHAPTER XI SUMMARY

CHAPTER XII NEDERLANDSE SAMENVATTING VOOR NIET-INGEWIJDEN

CHAPTER XIII DANKWOORD

CHAPTER XIV CURRICULUM VITAE

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