The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats

Authors
  • I Buffel
  • A. Meurs
  • R. Raedt
  • V. De Herdt
  • L. Decorte
  • L. Bertier
  • J. Delbeke
  • W. Wadman
  • K. Vonck
  • P. Boon
Publication date 2014
Journal International Journal of Neural Systems
Volume | Issue number 24 | 1
Pages (from-to) 1430005
Number of pages 10
Organisations
  • Faculty of Science (FNWI) - Swammerdam Institute for Life Sciences (SILS)
Abstract
Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response--100 μA), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 μA) and/or low frequency (5 Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough
Document type Article
Language English
Published at https://doi.org/10.1142/S0129065714300058
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