Heparins, cancer and thrombosis: clinical and experimental studies

Thesis

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Titlepage

CONTENTS

VOORWOORD

INTRODUCTION

DO HEPARINS DO MORE THAN JUST TREAT THROMBOSIS? THE INFLUENCE OF HEPARINS ON CANCER SPREAD

THE COMPLEX EFFECTS OF HEPARINS ON CANCER PROGRESSION AND METASTASIS IN EXPERIMENTAL STUDIES

THE EFFECTS OF UNFRACTIONATED HEPARIN ON SURVIVAL OF PATIENTS WITH MALIGNANCY. A SYSTEMATIC REVIEW

THE EFFECTS OF VITAMIN K-ANTAGONISTS ON SURVIVAL OF PATIENTS WITH MALIGNANCY. A SYSTEMATIC REVIEW

UNFRACTIONATED AND LOW MOLECULAR WEIGHT HEPARIN AFFECT FIBRIN STRUCTURE AND ANGIOGENESIS IN VITRO

IN VIVO TREATMENT OF RATS WITH UNFRACTIONATED HEPARIN OR LOW MOLECULAR WEIGHT HEPARIN DOES NOT AFFECT EXPERIMENTALLY INDUCED COLON CARCINOMA METASTASIS

TREATMENT WITH UNFRACTIONATED HEPARIN OR LOW MOLECULAR WEIGHT HEPARIN DOES NOT AFFECT GROWTH OF SARCOMAS AND TUMOR-ASSOCIATED ANGIOGENESIS IN AN EXPERIMENTAL RAT MODEL

DOES LOW MOLECULAR WEIGHT HEPARIN IMPROVE THE SURVIVAL OF CANCER PATIENTS? AN INTERIM SAFETY REPORT OF A RANDOMIZED DOUBLE BLIND PLACEBO-CONTROLLED STUDY

SHOULD THE TREATMENT OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH CANCER BE DIFFERENT?

SUBSEQUENT DIAGNOSIS OF MALIGNANCY IN PATIENTS PRESENTING WITH VENOUS THROMBOEMBOLISM A REVIEW AND AN ANALYSIS OF NUMBER NEEDED TO SCREEN

SUMMARY AND GENERAL DISCUSSION

SAMENVATTING

CO-AUTHORS

DANKWOORD

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