Safety management in mechanical heart valve replacement and oral anticoagulant therapy

Thesis

Cover

Titlepage

Contents

Chapter 1 Introduction

Chapter 2 Controlling the Risks of Mechanical Heart Valve Failure using Product Life Cycle-based Safety Management

Chapter 3 Retrieval Analysis of Mechanical Heart Valves: Impact on design and clinical practice

Chapter 4 Liability for Failed Mechanical Heart Valves: an Accident and Risk Perception Analysis

Chapter 5 Pharmacological Strategies aimed to reduce Excessive Blood Loss in Cardiac Surgery, reduce Mortality and prevent Re-Exploration: a Meta-Analysis on Clinically Relevant End Points

Chapter 6 Failure Mode & Effect Analysis and Fault Tree Analysis in the use of the CoaguChek® Prothrombin Time Monitor

Chapter 7 The Accuracy of Home-Monitoring of Oral Anticoagulant Therapy in Comparison to a Standard Laboratory Setting

Chapter 8 A Randomized Crossover Comparison between Oral Anti-coagulation Self-Management and Management by the Thrombosis Service in the Netherlands

Chapter 9 Quality of Life in Patients on Self-Management compared to Management by the Thrombosis Service in the Netherlands

Appendix A

Appendix B

Summary

Samenvatting

Dankwoord

Curriculum Vitae

Cover