Arrhythmogenic mechanisms in inherited and acquired cardiac diseases

Dysregulation of cardiac electrical activity can lead to disturbances of normal cardiac rhythm. Such arrhythmias can occur in the setting of inherited, as well as acquired disease. Independent of the underlying disease, often, genetic and acquired risk factors both contribute to arrhythmogenesis and as such are both important for determining an individual’s arrhythmic risk. Likewise, mechanisms underlying both types of factors must be addressed for development of antiarrhythmic therapies. In the current thesis we aimed to discover mechanistic pathways involved in arrhythmia in inherited disease and define arrhythmic risk in COVID-19.