Synthesis of Enantiopure Vicinal Halohydrins Using a Sequence of Haloperoxidase and Lipase
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| Publication date | 06-08-2024 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | Issue number | 366 | 15 |
| Pages (from-to) | 3290-3296 |
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| Abstract | Vicinal halohydrins are key building blocks to produce bioactive molecules and drugs, especially if they can be obtained in enantiomerically pure form. In this study, we present a bi-enzymatic sequence that allows to obtain vic-halohydrins through a photochemoenzymatic olefin hydroxy halogenation followed by a lipase catalysed kinetic resolution. The absolute configuration of the resulting products was determined using Mosher's method |
| Document type | Article |
| Language | English |
| Published at | https://doi.org/10.1002/adsc.202400516 |
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Synthesis of Enantiopure Vicinal Halohydrins Using a Sequence of Haloperoxidase and Lipase
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