Coherent Anti-Stokes Raman Scattering Microspectroscopic Kinetic Study of Fast Hydrogen Bond Formation in Microfluidic Devices
| Authors |
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| Publication date | 2013 |
| Journal | Analytical Chemistry |
| Volume | Issue number | 85 | 19 |
| Pages (from-to) | 8923-8927 |
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| Abstract | The kinetics of a key noncovalent, hydrogen bonding interaction was studied in situ using coherent anti-stokes Raman scattering (CARS) microspectroscopy in a microfluidic device. The association of model compounds, pyridine and hexafluoroisopropanol, was quantitatively monitored with submicrometer resolution. Lower limits for the very high formation and dissociation rate constants of the model 1:1 pyridine-hexafluoroisopropanol hydrogen bonded complex in dichloromethane-d2 were determined to be k1 > 105 M-1s-1 and k-1 > 333.3 s-1, respectively. |
| Document type | Article |
| Language | English |
| Published at |
https://doi.org/10.1021/ac402233n
(Final published version)
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